What is "CLIP" hormone?

Does this help? http://en.wikipedia.org/wiki/Corticotro … te_peptide

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I would add that the synthesis of CLIP is a wonderful example of how many biologically active hormones are cleaved from larger (usually inactive) precursor molecules by various enzymes.

The precursor in this case is pro-opiomelanocortin (POMC) which gives rise to numerous peptides that can act as hormones or neuromodulators/neurotransmitters - these peptides include gamma-melanocyte stimulating hormone and adrenocorticotropic hormone (ACTH), the latter being further cleaved to alpha-melanocyte stimulating hormone and CLIP, and beta-lipotropin which is processed to gamma-lipotropin (and then beta-melanocyte stimulating hormone) and beta-endorphin. Many of these molecules can be further changed by post-translational modifications (e.g., acetylation, phosphorylation).The processing of POMC can also be tissue-dependent, e.g., different products produced in the brain versus the pituitary gland. The POMC peptides generally act on G protein-coupled receptors to elicit their biological responses.